Hi Bob,
I recently got the same camera and have been having a difficult time with the calibration frames. I am a beginner so take this with the proverbial grain of salt.
Initially I was having the same problem of the flats not working. There was vignetting and "amp glow" and correcting with flats left one side too dark and the other (amp glow) too bright, best case. Also these areas fell within the same adu as parts of the galaxy image so taking them out in a stretch also wiped out parts of the image.
Scouting the forums: There are some discussions on CN and elsewhere that discuss nonlinearities in the sensor and electronics of this camera. The old rules for calibration frames from CCD cameras need to be modified a bit. The recommendations were:
Flats - keep exposures over .2 sec, .5 optimal. My filters are new and little if any dust so I used the Ha filter to get exposures this long (tshirt method, daytime, .5 sec). I used the peak at 60% on the SharpCap histogram. (about 39,000adu). I took other flats as well but this worked.
Bias - short exposures don't work correctily. Use 1 second.
In the one image I have taken and processed since following this advice, I have gotten very a good result using flats, dark flats, and bias frames. The vignetting and amp glow are gone, and the image is intact and full range. This is monochrome, I've only processed the L image (last night).
Unfortunately, the dark frames do not work. I'm running the camera at -20C so this isn't as bad as uncooled. I'm not seeing hot pixels. But the histogram for the darks is bizarre - the low end peak is at a higher adu than the light frames. So using the flats (I'm using DSS) ruins the image by taking out much of the midrange. It is as though something is turning up the gain or offset on the dark exposure, but this isn't shown in the camera setting logged by SharpCap.
I'm a newbie so there may be something else I'm doing wrong. But such are my results to date. I'm going to email ZWO and ask for guidance on calibration frames. I'll also retake the darks. I took them during daytime with the telescope (C11) capped and black plastic bags covering the scope and image train. Maybe some light leaked in, but I don't think so. That would be non-uniform and I don't see that on a stretched dark frame.
This camera is really popular so you would think there would be some definitive info out there.
Steve