If you're often opening the imaging train when swapping it around between scopes, frequently rack the focuser all the way in for storage and back out again for imaging which sucks air in as it extends, or just shoot from an extremely dusty location, then trying to keep things totally clean might be a bit hard. But I've been getting extremely good results with fairly minimal upkeep with my setup by using those APS-C sensor swabs you can find on amazon. They cost about 50 cents each, though I bet you could find them cheaper on ebay or aliexpress if you don't mind waiting a month.
It's good to mention that if it's really dusty inside, you should definitely air-dust with a squeeze-duster first before going to the swabs in case there are any large particles that can get dragged along and scratch things, and you should only really take one swipe per side of the swab too as an extra precaution.
I'll admit that I am lazy with getting out new swabs every couple swipes though, and have a trick that works well to get more use out of each swab and makes them slightly more effective too. If you pinch the plastic packaging and pull the fresh swab out quickly, it picks up the slightest bit of static charge that sucks up loose dust really well without having to press the swab right against the surface to grab the dust. Afterwards, a quick flick on the plastic handle will knock off anything loose, and I can usually swipe it again with good success. I've found that I only really get one shot with the static trick though, it doesn't seem to work again a second time. Also if it's rather humid out, the static won't last more than a few seconds either so it's something to do swiftly and precisely lol.
Cleaning it out entirely sounds time consuming but once it's clean I never spend more than 2-3 minutes any time I open/close the system again(which isn't very often). If I'm taking off my reducer from the OAG/filter wheel, then I'll just take a peek with my mini flashlight to see if there's anything obvious to blow out before it falls inside. If I'm opening the filter wheel or going any deeper than that, before I close it up I'll get the flashlight again(I use a streamlight microstream usb) to do a thorough check and air-dusting, and maybe some light swipes with a fresh swab if needed.
An extremely helpful thing that might get overlooked is after you've used a fresh swab on any critical/optical surfaces, take 5 more seconds to swipe it over any other non-optical surfaces inside the filterwheel housing/cover before tossing it. This took care of 99% of the random migrating dust I was shooting new flats to correct for - the kind that seems to appear out of nowhere even though the system hasn't been opened recently, then disappears/migrates again a few hours or nights later. If I wanted exact flats for each image set to correct for loose dust moving around, I'd probably end up spending more time shooting new flats than it probably takes to manage the dust in the first place. The only time I really need to shoot new flats now is when I rotate the camera assembly to prevent that embossed ring artifact, but even then I'll usually be lazy first and try my previous flats again and see if DBE can take care of any differences before I'll go shoot new flats lol.
A last side-note, I originally had been using a small bottle of cleaning solution that came with a sensor cleaning kit, but found that it left an extremely faint residue when it evaporated. I figure that since I'm (hopefully) not getting oily fingerprints or sticky debris in the imaging system, the solution was doing more harm than good and have since stopped using any solution entirely.
Clear skies, and clean flats

-Mike H.
