Absolutely suggested to take the same exposure time on RGB. It will get easier color calibration. Another advice is to shoot in a roulette mode R-G-B-R-… if you have an automatic filterwheel. This will grant homogeneous gradients, far easy to remove directly in the RGB combined image.
With CMOS, I always suggest also to keep Gain=0 to preserve dynamic range to the maximum scale, then go for the longest exposure you can. Instead looking at the histogram peak, I use to look at its left foot: it should not shift much from the graph’s 0 (this would mean your background isn’t black). I also look at histogram’s peak because it shouldn’t be cut on its top (saturated parts). M42 is quite a particular object because it hasn’t any background in its surroundings, so just be careful to not saturate nebula. Even in this case, M42 is particular: the core needs 10s exposures, the surroundings will be better with 1800s. Take both if you can, much 1800s shots and 3x10s, 3x60s, 3x120s, 3x300s, 3x600s, 3x1200s to achieve a perfect HDR composition.
If you want to gather also luminance, it is recommended to get longer times on it, both for single exposure and total integration.
I took M42 HDR last year. Try to take a look in my gallery to get more info
