It might be clouds, seeing, wind, moonlight–whatever disfunction there is, you need to make a decision.
To make a decision you need data. You need to get to know each target, based on brightness, altitude range and detail that it contains. If the target is low in the sky FWHM will be much higher than a target overhead, and skyglow will be much worse. So what is good for FWHM and skybackground or a low target is bad for a high target. If there is little detail, FWHM is not so critical–but getting enough exposure is. If the target is faint, you will not worry so much about detail and FWHM, but clouds, full moon will kill what you are trying to do. If the object is bright with detail, worry about seeing and wind, skyglow and light clouds will not be a huge issue–though you might need to fix halos around bright stars. For examole I image globular clusters when the full moon is in the way, not faint nebulosity.
I generally need at least 5 nights for a target, often more. So initially you don't know what can be acheived for this target. Thus for a new target go out unless it is totally hopeless, take images and record FWHM, background, star shapes. In fact a bad night is good to start a new target, you can use the time to get the framing, settings, and see if it at all looks hopeful to try when conditions are better. And it may turn out the data was perfectly usable. After a few nights you realize this is not up to par and quit,or this is a great night, go as long as you can. And remember if you get 50% retention of good images on a bad night of 6 hours, that is equal to 100% on a good night of 3 hours. For my local conditions, 3 hours of good data is golden, so I go for the 50% for sure. But if your yield of usable images is 10%, go to bed…
Finally if there are a lot of clouds, poor seeing or wind, shorten exposures. Your yield of usable images will go up, as the clouds move quickly in your field of view, they will average out well with shorter exposures. The exposure time may not be ideal for noise, but if you don't go out and get any reasonable exposures, you will not improve your S/N. You must collect some data, even if it may not be perfect in all respects.
Put all your data together and discard what is not working–I find once you have 20 hours of good exposures, it is not difficult to discard 3 hours that are not up to par, even though at the time it was hard earned data.
In short be generous in what images you take, be critical of what images you keep.
Clear and steady skies
Rick