Got the same problem, I reached out to Syqon. Here’s their answer, it worked for me, hope this helps you, it did for me.
Thank you for reaching out and for providing such detailed information regarding the issue you are experiencing with Prism for PixInsight.
I would like to sincerely apologize for the frustration this has caused. The issue you are encountering with Windows 11 Defender is what is known as a "false positive." Because Prism is a relatively new software, it has not yet built up a high enough reputation score with antivirus databases, leading Windows Defender to mistakenly flag the .exe file as a threat.
To resolve this and prevent Defender from deleting or quarantining the file, you will need to add an exclusion. Here are the steps to follow:
1. Go to Start > Settings > Privacy & security > Windows Security > Virus & threat protection.
2. Under Virus & threat protection settings, select Manage settings.
3. Scroll down to Exclusions and select Add or remove exclusions.
4. Click Add an exclusion and select Folder.
5. Select the folder where you have extracted (or intend to extract) the Prism files.
Once this exclusion is set, you should be able to extract the zip file and run the .exe without Windows Defender interfering.
We appreciate your patience while the software gains more recognition with security providers. Please let us know if you need any further assistance getting everything up and running.
Best regards,
Lara
SyQon Technology