My experience is if you are doing a bi-color Ha+OIII (HOO) image of emission nebula it is more likely the nebula is dominated by Ha. I will bring in a processed Ha image as a luminance layer. This usually strengthens the nebula structure. If there are destink OIII areas that are moninated by blue/blue Green, I will mask those areas and bring them out with a OIII layer.
A Ha luminance layer can also apply to a Hubble palette emission nebula image. Since the Ha data brought is as green gas to be weakened and the OIII/SII strengthened, the Ha structure can be lost. A Ha luminance will bring that back.
The RGB data is used for star color. If it is strong enough, it can be used as a color layer to make the Ha\OIII image look more natural.
When doing narrow band processing, A traditional luminance layer isn't very effective. It no longer is the channel that depicts the most resolution. With emission nebula, that will be the Ha channel.
These comments are based on using PhotoShop. Other software application will vary , but the basic concepts are the same.
Lynn K.