about quality degrading further away from the zenith, this is not much of a problem when doing monochrome narrowband, of course, unless I'm imaging something barely visible on the horizon, which I would never do.
when I think it's not worth it to continue, it's because the DSO just looks "bland" on the subs, but this is a false feeling that I shouldn't follow; the big difference is when you have the 20hrs of data stacked up - in a lot of cases, that's when you'll see the real beauty and processing potential; I'm focusing now on one object, and I shouldn't image any other object until this one is finished, that's the way I think, and it requires a lot of self control because I feel like going to 10 different targets the same night and doing live stacking; I have an EAA addiction

I don't spend one night using more than one filter (anymore, unless, I'm doing a narrowband project and need maybe 1-3hrs of RGB data for stars, which can be taken in one night)
so, the approximate hours I spend on one target, including bad subs, these days, is about 5-6hrs, maybe 7hr if I rush to set up at dusk
and after trashing bad subs (because of dawn approaching or bad guiding), I usually end up with about 5 hours of useable data