Regarding the scope…
I can't give you the same kind of specifics that MessierMan did, but I originally (2012, 2013) started with visual observation newtonians, and I had a lot of problems with them for imaging. They were fine for visual observation and it really tickled my interest in astrophotography (which I started around the same time), but in the long run I ended up using a telephoto camera lens, and then eventually bought proper imaging telescopes. I suspect that, regardless of what camera you use, most of your struggles will be in taming the scope. This would be doubly true if you live and image in a light polluted area, where LP is going to swamp a lot of the various differences in cameras…
Regarding the cameras…
I've long been wary of the ASI 294MC, as even from the very beginning after its initial release, people have been reporting calibration issues. IIRC the assumption boils down to the design of the sensor package, which limits how evenly it can be cooled. This doesn't necessarily always present a problem, and if you are imaging brightly lit fields, it might not be an issue. For fainter fields, galaxy and glob imaging in particular, its something to at least consider. A quick search will usually bring up a lot of threads around the internet about the 294MC and its calibration issues, which span many years now.
Being an OSC camera (one shot color), as Andrea mentioned, it would be a more forgiving camera, easier to use, etc. since you don't have to worry about additional equipment, cables, etc. hanging off the front of your newt there… There are other OSC cameras, though, and the 294 is not the only option. There are even color versions of the 183-based cameras.
I have an ASI183MM, which is very similar to the QHY183M. Both are excellent cameras. Smaller sensor, and smaller pixels, and it does have the starburst glow. The glow is something to consider about this camera, but it does calibrate out just fine with well-matched darks. From a noise standpoint, while its not the lowest noise, I've always been pleased with the characteristic of the noise from these cameras. Its an very nice gaussian profile.
The pixels are small, 2.4 microns, with this camera. That said, you have quite a lot of pixels, and you don't necessarily have to stick with the native size. I usually downsample my images by a factor of 2x, and still have excellent detail and the downsampling gives me excellent SNR. I usually downsample near the very end of my post-processing.
FWIW, both of these cameras these days, are actually "older" technology. Newer than most CCD tech, but older than the creme of the crop CMOS sensors around these days. Just curious, have you considered a camera like the ASI or QHY 533M cameras? There are color (OSC) versions, and they are much more sensitive cameras than either of the other two. They have high conversion gain (HCG) modes with high dynamic range and very low read noise. They don't look all that expensive either, around $800. Smaller sensor than the ASI294 of course…but, from what I've seen, the 533 is an excellent sensor with very good, even cooling. The 533, unlike the 183, does NOT have the starburst amp glow, which is a bonus. There are also the APS-C sized sensors, if you wanted something larger, although you would need to make sure your scope produces an image circle large enough for that.