Hello,
I've tried different settings but didn't see much of a difference, what really made the difference was the usb connexion.
If i use my 5m usb 3 extension cable with this camera, the mount, filter wheel and auto focuser on a usb hub everything will work, but if I add a guide camera on top of it I can expect crashes or lost images, on both cams. I tried to use a powered usb cable, but the camera wasn't recognized. I used a powered usb hub, it would add some stability but I would still have problems.
The best solution I found, was to plug everything but the QHY294M on a usb3 hub, itself connected to a 5m cable and then to the computer. And to use a separate usb plug, with an extension cable, for the QHY294M.
Its the only way I've found to have everything perfectly stable, and still get about 5 meters between the pc and the mount.
Hope this helps, clear skies.